The Association between Parathyroid Hormone Levels and the Cardiorenal Metabolic Syndrome in Non-Diabetic Chronic Kidney Disease

Aims: The relationship between parathyroid hormone (PTH) and the cardiorenal metabolic syndrome was examined among non-diabetic persons with chronic kidney disease (CKD). Methods: In a cross-sectional analysis, the relationship between PTH levels and the cardiorenal metabolic syndrome was investigated in 3,215 non-diabetic participants in the National Kidney Foundation-Kidney Early Evaluation Program (KEEP 2.0) found to have CKD (eGFR ! 60 ml/ min/1.73 m 2 ). Results: In unadjusted analyses, the prevalence of the cardiorenal metabolic syndrome increased along increasing PTH quartiles (31.7, 33.8, 37.3, and 48.7%, respectively, p for trend ! 0.0001). After multivariate adjustment, as compared to the first PTH quartile, odds of the cardiorenal metabolic syndrome were 16% (p = 0.18), 35% (p = 0.006), and 80% (p ! 0.0001) higher for the second, third, and fourth quartiles, respectively. When taken as a continuous predictor, each standard deviation increase of natural log transformed PTH was associated with Received: March 2, 2011 Accepted: March 8, 2011 Published online: April 15, 2011 Georges Saab, MD Department of Internal Medicine, Renal Division Washington University School of Medicine Campus Box 8126, 660 South Euclid Ave, St. Louis, MO 63110 (USA) Tel. +1 314 362 4547, E-Mail gsaab @ dom.wustl.edu www.karger.com/crm D ow nl oa de d by : 54 .7 0. 40 .1 1 11 /1 9/ 20 17 2 :3 1: 13 P M 124 Cardiorenal Med 2011;1:123–130 DOI: 10.1159/000327149 Saab et al.: PTH and Cardiorenal Syndrome www.karger.com/crm © 2011 S. Karger AG, Basel Published online: April 15, 2011 26% (p ! 0.0001) higher odds of the cardiorenal metabolic syndrome. The association of PTH with the cardiorenal metabolic syndrome was not modified by age or gender (p for interaction was not significant for both modifiers). Conclusions: Among an outpatient non-diabetic population with CKD, higher PTH levels were associated with a higher prevalence of the cardiorenal metabolic syndrome. Copyright © 2011 S. Karger AG, Basel